The NADPH oxidase of professional phagocytes - prototype of the NOX electron transport chain systems

被引：365

作者：

Cross, AR

Segal, AW

机构：

[1] UCL, Dept Med, Ctr Mol Med, London WC1E 6JJ, England

[2] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2004年 / 1657卷 / 01期

基金：

英国惠康基金;

关键词：

free radical; flavin; cytochrome; neutrophil; microbicidal; enzyme; NOX; antioxidant; ion channel;

D O I：

10.1016/j.bbabio.2004.03.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The NADPH oxidase is an electron transport chain in "professional" phagocytic cells that transfers electrons from NADPH in the cytoplasm, across the wall of the phagocytic vacuole, to form superoxide. The electron transporting flavocytochrome b is activated by the integrated function of four cytoplasmic proteins. The antimicrobial function of this system involves pumping K+ into the vacuole through BKCa channels, the effect of which is to elevate the vacuolar pH and activate neutral proteases. A number of homologous systems have been discovered in plants and lower animals as well as in man. Their function remains to be established. (C) 2004 Published by Elsevier B.V.

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页码：1 / 22

页数：22

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