Microbicides: A new approach to preventing HIV and other sexually transmitted infections

被引:155
作者
Stone, A [1 ]
机构
[1] Family Hlth Int, London E1 1EE, England
关键词
D O I
10.1038/nrd959
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Many chemical agents can block human immunodeficiency virus (HIV) infection in the laboratory. Scientists are investigating which of these, used intravaginally by women, will safely prevent the sexual transmission of HIV in humans. Several such products - microbicides will soon be tested in populations at high risk for HIV, and others are waiting in the wings. Microbicides will provide a low-cost method, controlled by women, for protection against HIV, other sexually transmitted pathogens and unwanted pregnancy, and will therefore have global public-health benefits.
引用
收藏
页码:977 / 985
页数:9
相关论文
共 65 条
[1]  
Alexander NJ, 1996, AIDS, V10, P1
[2]  
[Anonymous], 2002, MOB MICR DEC DEC
[3]   Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent [J].
Balzarini, J ;
Naesens, L ;
Verbeken, E ;
Laga, M ;
Van Damme, L ;
Parniak, M ;
Van Mellaert, L ;
Anné, J ;
De Clercq, E .
AIDS, 1998, 12 (10) :1129-1138
[4]  
BARNHART KT, 2002, MICR 2002 C
[5]   Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier [J].
Bomsel, M .
NATURE MEDICINE, 1997, 3 (01) :42-47
[6]   The topical microbicide PRO 2000 protects against genital herpes infection in a mouse model [J].
Bourne, N ;
Bernstein, DI ;
Ireland, J ;
Sonderfan, AJ ;
Profy, AT ;
Stanberry, LR .
JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (01) :203-205
[7]   HIV-1 entry and how to block it [J].
Brelot, A ;
Alizon, M .
AIDS, 2001, 15 :S3-S11
[8]   Men's attitudes towards a potential vaginal microbicide in Zimbabwe, Mexico and the USA [J].
Coggins, C ;
Blanchard, K ;
Friedland, B .
REPRODUCTIVE HEALTH MATTERS, 2000, 8 (15) :132-141
[9]   Preliminary safety and acceptability of a carrageenan gel for possible use as a vaginal microbicide [J].
Coggins, C ;
Blanchard, K ;
Alvarez, F ;
Brache, V ;
Weisberg, E ;
Kilmarx, PH ;
Lacarra, M ;
Massai, R ;
Mishell, D ;
Salvatierra, A ;
Witwatwongwana, P ;
Elias, C ;
Ellertson, C .
SEXUALLY TRANSMITTED INFECTIONS, 2000, 76 (06) :480-483
[10]  
COLE A, 2002, MICR 2002 C