Antimicrobial spectrum and activity of NVP PDF-713, a novel peptide deformylase inhibitor, tested against 1,837 recent Gram-positive clinical isolates

Continued emergence of antimicrobial resistances among gram-positive pathogens requires further development of compounds with novel modes of action. The peptide deformylase inhibitor NVP PDF-713 was tested against 1,837 recent strains of Gram-positive organisms. All NVP PDF-713 MICs were at less than or equal to4mug/mL except for 6 enterococci (0.3% of strains overall). NVP PDF-713 MIC90 results were: Staphylococcus aureus, beta-haemolytic and viridans group streptococci and Streptococcus bovis at I mug/ml; coagulase-negative staphylococci, Streptococcus pneumoniae, and Listeria spp, at 2 mug/mL; and the enterococci at 4 mug/mL. NVP PDF-713 appears to be a promising new agent worthy of continued in vivo development. (C) 2004 Elsevier Inc. All rights reserved.