Evaluation of the potential carcinogenic activity of Senna and Cascara glycosides for the rat colon

被引：26

作者：

Mereto, E ^{[1
]}

Ghia, M ^{[1
]}

Brambilla, G ^{[1
]}

机构：

[1] UNIV GENOA,IST FARMACOL,I-16132 GENOA,ITALY

来源：

CANCER LETTERS | 1996年 / 101卷 / 01期

关键词：

Senna glycosides; Cascara glycosides; rat colon carcinogenesis;

D O I：

10.1016/0304-3835(96)04129-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Anthraquinone glycosides of Senna and Cascara were investigated for their ability to induce aberrant crypt foci (ACF) in the rat colon mucosa, which are considered putative preneoplastic lesions. Dietary exposure to high doses of these glycosides for 56 successive days did not cause the appearance of ACF or increase the incidence of ACF induced by 1,2-dimethylhydrazine (DMH). However, in rats treated with both DMH and the highest dose of glycosides, the average number of aberrant crypts per focus, considered a consistent predictor of tumor outcome, was higher than in rats given DMH alone. These findings suggest that Senna and Cascara glycosides might behave as weak promoters in rat colon carcinogenesis.

引用

页码：79 / 83

页数：5

共 26 条

[1] OBSERVATION AND QUANTIFICATION OF ABERRANT CRYPTS IN THE MURINE COLON TREATED WITH A COLON CARCINOGEN - PRELIMINARY FINDINGS [J].