Lipase-based HPLC stationary phase: enantioselective synthesis of 2-substituted 1,3-propanediol monoacetates

被引：32

作者：

Bertucci, C

Petri, A

Felix, G

Perini, B

Salvadori, P

机构：

[1] Univ Pisa, CNR, Ctr Macromol Stereordinate & Otticamente Attive, Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy

[2] Univ Bordeaux 1, Ecole Natl Super Chim & Phys Bordeaux, F-33405 Talence, France

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 22期

关键词：

D O I：

10.1016/S0957-4166(99)00478-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Pseudomonas cepacia lipase (PCL) has been immobilized by coating the enzyme on an epoxysilica HPLC column. The biocatalyst has been successfully used for the preparation of both the enantiomers of 3-acetoxy-2-benzyl-propan-1-ol and of 3-acetoxy-2-methylpropan-1-ol. The immobilized enzyme is active after months of use either in aqueous or in organic media. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4455 / 4462

页数：8

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