The trypanosome lytic factor of human serum and the molecular basis of sleeping sickness

被引：30

作者：

Vanhamme, L ^{[1
]}

Pays, E ^{[1
]}

机构：

[1] Univ Brussels, IBMM, Mol Parasitol Lab, Dept Mol Biol, B-6041 Gosselies, Belgium

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2004年 / 34卷 / 08期

关键词：

Trypanosoma brucei; trypanosome lytic factor; haptoglobin-related protein; apolipoprotein L-1; serum resistance-associated protein; lysosome;

D O I：

10.1016/j.ijpara.2004.04.008

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Trypanosoma brucei brucei infects a wide range of mammals but is unable to infect humans because this subspecies is lysed by normal human serum (NHS). The trypanosome lytic factor is associated with High Density Lipoproteins (HDLs). Several HDL-associated components have been proposed as candidate lytic factors, and contradictory hypotheses concerning the mechanism of lysis have been suggested. Elucidation of the process by which Trypanosoma. brucei rhodesiense resists lysis and causes human sleeping sickness has indicated that the HDL-bound apolipoprotein L-I (apoL-I) could be the long-sought after lytic component of NHS. This research also allowed the identification of a specific diagnostic DNA probe for T b. rhodesiense, and may lead to the development of novel anti-trypanosome strategies for use in the field. (C) 2004 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：887 / 898

页数：12

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