Hydrolytic antibodies: Variations on a theme

被引：83

作者：

MacBeath, G ^{[1
]}

Hilvert, D ^{[1
]}

机构：

[1] SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA

来源：

CHEMISTRY & BIOLOGY | 1996年 / 3卷 / 06期

基金：

美国国家卫生研究院; 加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S1074-5521(96)90091-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Comparison of four independently-derived hydrolytic antibodies reveals striking similarities in their active sites, A common structural motif appears to be induced when the immune system is challenged with antigens containing aryl phosphonate and phosphonamidate groups, and key variations on this 'theme' must account for the observed differences in catalytic efficacy and mechanism. The limited structural repertoire accessed through standard immunization procedures suggests that new approaches may be needed to produce antibody catalysts with enzyme-like efficiencies.

引用

页码：433 / 445

页数：13

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