Intraoperative bleeding during vitrectomy for diabetic tractional retinal detachment with versus without preoperative intravitreal bevacizumab (IBeTra study)

被引:64
作者
Lucena, D. da R. [1 ]
Ribeiro, J. A. S. [1 ]
Costa, R. A. [1 ,2 ]
Barbosa, J. C. [3 ]
Scott, I. U. [4 ,5 ]
de Figueiredo-Pontes, L. L. [6 ]
Jorge, R. [1 ]
机构
[1] Univ Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
[2] Hosp Olhos Araraquara, Maclma Macular Imaging & Treatment Div, Sao Paulo, Brazil
[3] Sao Paulo State Univ, Dept Exact Sci, Sao Paulo, Brazil
[4] Penn State Coll Med, Dept Ophthalmol, Hershey, PA USA
[5] Penn State Coll Med, Dept Publ Hlth Sci, Hershey, PA USA
[6] Univ Sao Paulo, Hematol Lab, Sao Paulo, Brazil
关键词
COHERENCE TOMOGRAPHY FINDINGS; MACULAR DEGENERATION; RETINOPATHY; AVASTIN; MANAGEMENT; INJECTION; THROMBIN;
D O I
10.1136/bjo.2008.151233
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Aims: To compare the amount of intraoperative intraocular bleeding in patients with diabetes with macula-involving tractional retinal detachment (TRD) undergoing pars plana vitrectomy (PPV) with and without preoperative intravitreal bevacizumab (IVB) injection. Methods: An institutional study was carried out with consecutive patients with diabetic retinopathy and macula-involving TRD of recent (3 months) onset who were randomly assigned to PPV only (PPV group) or PPV combined with one IVB (1.5 mg/0.06 ml) injection 2 weeks prior to surgery (bevacizumab (BEV)/PPV group). All patients underwent 23-gauge PPV 3 weeks after baseline. The main outcome measure was erythrocyte count in the fluid retrieved from the vitrectomy cassette using a Neubauer counting chamber. Results: The study included 20 patients. The mean erythrocyte count was 14865x10(3) (SD 19332x10(3); median 4500x10(3)) cells in the BEV/PPV group, and 176240x10(3) (SD 108375x10(3); median 166600x10(3)) cells in the PPV group. The mean erythrocyte count was significantly lower in the BEV/PPV group than in the PPV group (p < 0.0001). No major adverse events were identified. Conclusion: Preoperative IVB injection was associated with reduced intraocular bleeding during 23-gauge PPV for diabetic macula-involving TRD. Further studies are needed to confirm our preliminary findings.
引用
收藏
页码:688 / 691
页数:4
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