Circumventricular organs and fever

被引:62
作者
Takahashi, Y
Smith, P
Ferguson, A
Pittman, QJ
机构
[1] UNIV CALGARY, NEUROSCI RES GRP, FAC MED, DEPT PHYSIOL & BIOPHYS, CALGARY, AB T2N 4N1, CANADA
[2] QUEENS UNIV, DEPT PHYSIOL, KINGSTON, ON K7L 3N6, CANADA
关键词
area postrema; subfornical organ; organum vasculosum of the lamina terminalis; lipopolysaccharide; prostaglandin; cytokine;
D O I
10.1152/ajpregu.1997.273.5.R1690
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We have examined the roles of three circumventricular organs, the area postrema, the subfornical organ, and the organum vasculosum of the lamina terminalis (OVLT), as possible access points for circulating pyrogens to cause fever. In conscious, unrestrained rats prepared with telemetry devices, intracerebroventricular cannulas, and intravenous catheters, body temperature was monitored after intravenously administered lipopolysaccharide and, on a different occasion, after intracerebroventricular prostaglandin E-1. Lipopolysaccharide-induced fevers in sham control lesioned rats were indistinguishable from those observed in animals with lesions of the area postrema, the OVLT, or the tissue immediately adjacent to this structure (peri-OVLT). In contrast, rats with lesions of the subfornical organ displayed reduced fevers. In none of the groups of lesioned animals were prostaglandin E-1 fevers reduced. Thus lesions did not interfere with central thermogenic pathways responsive to prostaglandin. Our results indicate that subfornical organ neurons respond to circulating pyrogens and through their efferent projections activate central pathways involved in fever.
引用
收藏
页码:R1690 / R1695
页数:6
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