Current concepts concerning the role of leptin in reproductive function

被引:69
作者
Holness, MJ [1 ]
Munns, MJ [1 ]
Sugden, MC [1 ]
机构
[1] Queen Mary Univ London, St Bartholomews & Royal London Sch Med & Dent, Dept Diabet & Metab Med, Div Gen & Dev Med, London E1 4NS, England
基金
英国医学研究理事会;
关键词
lactation; leptin; neonatal growth; pregnancy; reproduction; sexual maturation;
D O I
10.1016/S0303-7207(99)00126-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Leptin has recently been implicated as having a role in sexual maturation and reproduction. This review describes recent findings regarding the putative reproductive functions of leptin within the context of the attainment of sufficient long-term fuel reserves to sustain and support pregnancy and lactation. The review considers the evidence, within the context of the development of hyperleptinaemia during pregnancy, that leptin has an important function to modulate maternal nutrient partitioning in order to optimise the provision of nutrients for fetal growth and development. It is suggested that, through modulation of maternal insulin secretion and hepatic metabolism, leptin integrates maternal nutrient storage to the nutrient requirements of the fetus. The importance of the placenta as a site of leptin synthesis and the potential role(s) of placentally derived leptin are evaluated in relation to maternal-fetal interactions during intrauterine development. The review also examines whether intrauterine growth retardation due to nutritional restriction reflects dysregulation of such cross-talk. Finally, the review describes emerging evidence for participation of leptin in lactation and neonatal growth. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:11 / 20
页数:10
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