Genetic dissection of systemic lupus erythematosus

被引：132

作者：

Wakeland, EK

Wandstrat, AE

Liu, K

Morel, L

机构：

[1] Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA

[2] Univ Florida, Ctr Mammalian Genet, Gainesville, FL 32610 USA

[3] Univ Florida, Dept Med, Gainesville, FL 32610 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(99)00039-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent progress towards elucidating the genetic basis for susceptibility to systemic lupus erythematosus (SLE) has provided insights into the manner in which individual susceptibility genes contribute to disease pathogenesis. Studies in animal models of systemic autoimmunity suggest that genes in three separate pathways contribute to the initiation and progression of systemic autoimmunity. Linkage studies in humans suggest that at least some susceptibility genes mediating disease in lupus-prone mice may also contribute to susceptibility in humans.

引用

页码：701 / 707

页数：7

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