Inhibition of Src kinase activity by 4-anilino-7-thienyl-3-quinolinecarbonitriles

被引：28

作者：

Boschelli, DH ^{[1
]}

Wang, DY ^{[1
]}

Ye, F ^{[1
]}

Yamashita, A ^{[1
]}

Zhang, N ^{[1
]}

Powell, D ^{[1
]}

Weber, J ^{[1
]}

Boschelli, F ^{[1
]}

机构：

[1] Wyeth Res, Chem Sci & Oncol, Pearl River, NY 10965 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(02)00302-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Based on a screening lead from a yeast-based assay to identify Src family kinase inhibitors, a series of 4-anilino-7-thienyl-3-quinolinecarbonitriles was prepared. When the thiophene ring was substituted with a water-solubilizing group in a 2,5-, 3,5- or 2,4-pattern, potent inhibition of Src kinase activity was observed. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2011 / 2014

页数：4

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