Haptoglobin genotypes are not associated with resistance to severe malaria in The Gambia

被引：32

作者：

Aucan, C

Walley, AJ

Greenwood, BM

Hill, AVS

机构：

[1] Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[2] London Sch Hyg & Trop Med, London WC1B 3DP, England

[3] MRC Labs, Banjul, Gambia

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2002年 / 96卷 / 03期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

malaria; Plasmodium falciparum; haptoglobin; gene polymorphisms; pathogenesis; The Gambia;

D O I：

10.1016/S0035-9203(02)90114-8

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The influence of haptoglobin polymorphisms on severe malaria occurrence was assessed in 1183 individuals from The Gambia. No significant association was found between severe malaria and either haptoglobin genotypes or phenotypes. The advantages of using a deoxyribomicleic acid-based haptoglobin typing method are discussed.

引用

收藏

页码：327 / 328

页数：2

相关论文

共 15 条

[1] HAPTOGLOBIN POLYMORPHISM AND ITS RELATIONSHIP TO MALARIA INFECTIONS IN THE GAMBIA [J].

BOREHAM, PFL ;

LENAHAN, JK ;

PORT, GR ;

MCGREGOR, IA .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1981, 75 (02) :193-200

[2] Haptoglobin polymorphism, iron metabolism and mortality in HIV infection [J].

Delanghe, JR ;

Langlois, MR ;

Boelaert, JR ;

Van Acker, J ;

Van Wanzeele, F ;

van der Groen, G ;

Hemmer, R ;

Verhofstede, C ;

De Buyzere, M ;

De Bacquer, D ;

Arendt, V ;

Plum, J .

AIDS, 1998, 12 (09) :1027-1032

[3] Association of the haptoglobin phenotype (1-1) with falciparum malaria in Sudan [J].

Elagib, AA ;

Kider, AO ;

Åkerström, B ;

Elbashir, MI .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1998, 92 (03) :309-311

[4] AHAPTOGLOBINEMIA IN MELANESIA - DNA AND MALARIAL ANTIBODY STUDIES [J].

HILL, AVS ;

WHITEHOUSE, DB ;

BOWDEN, DK ;

HOPKINSON, DA ;

DRAPER, CC ;

PETO, TEA ;

CLEGG, JB ;

WEATHERALL, DJ .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1987, 81 (04) :573-577

[5] COMMON WEST AFRICAN HLA ANTIGENS ARE ASSOCIATED WITH PROTECTION FROM SEVERE MALARIA [J].

HILL, AVS ;

ALLSOPP, CEM ;

KWIATKOWSKI, D ;

ANSTEY, NM ;

TWUMASI, P ;

ROWE, PA ;

BENNETT, S ;

BREWSTER, D ;

MCMICHAEL, AJ ;

GREENWOOD, BM .

NATURE, 1991, 352 (6336) :595-600

[6]

HILL AVS, 1986, AM J HUM GENET, V38, P382

[7] EVALUATION OF C-REACTIVE PROTEIN AND HAPTOGLOBIN AS MALARIA EPISODE MARKERS IN AN AREA OF HIGH TRANSMISSION IN AFRICA [J].

HURT, N ;

SMITH, T ;

TANNER, M ;

MWANKUSYE, S ;

BORDMANN, G ;

WEISS, NA ;

TEUSCHER, T .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1994, 88 (02) :182-186

[8]

Kasvosve I, 2000, INT J TUBERC LUNG D, V4, P771

[9]

Langlois MR, 1996, CLIN CHEM, V42, P1589

[10] Haptoglobin polymorphism and chronic hepatitis C [J].

Louagie, HK ;

Brouwer, JT ;

Delanghe, JR ;

DeBuyzere, ML ;

LerouxRoels, GG .

JOURNAL OF HEPATOLOGY, 1996, 25 (01) :10-14