Anti-gonococcal activity of gemifloxacin against fluoroquinolone-resistant strains and a comparison of agar dilution and Etest methods

被引：12

作者：

Jones, RN ^{[1
]}

Deshpande, LM ^{[1
]}

Erwin, ME ^{[1
]}

Barrett, MS ^{[1
]}

Beach, ML ^{[1
]}

机构：

[1] Univ Iowa, Coll Med, Dept Pathol, Div Med Microbiol, Iowa City, IA 52242 USA

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2000年 / 45卷

关键词：

D O I：

10.1093/jac/45.suppl_3.67

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Gemifloxacin is a novel quinolone with excellent activity against Gram-positive and some Gram-negative pathogens. Its activity was tested against 150 Neisseria gonorrhoeae strains, including 50 ciprofloxacin-resistant isolates, using reference agar dilution and Etest methods. Gemifloxacin was found to be highly potent against ciprofloxacin-susceptible strains (MIC90 0.008 mg/L), but was 16-fold less potent against ciprofloxacin-resistant gonococci. The order of quinolone potency against these fluoroquinolone-resistant mutants was: gemifloxacin (MIC90 0.12 mg/L)> trovafloxacin (0.25 mg/L)> moxifloxacin = grepafloxacin (0.5 mg/L)> ciprofloxacin (1 mg/L). Etest and reference agar dilution MIC results showed excellent correlation (r = 0.96) and >98% of MICs were within +/-1 log(2) dilution step (essential agreement). The excellent potency of gemifloxacin indicates its potential for the treatment of infections with quinolone-resistant N. gonorrhoeae.

引用

页码：67 / 70

页数：4

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