Ectopic semaphorin-1a functions as an attractive guidance cue for developing peripheral neurons

被引:53
作者
Wong, JTW [1 ]
Wong, STM [1 ]
O'Connor, TP [1 ]
机构
[1] Univ British Columbia, Dept Anat, Vancouver, BC V6T 1Z3, Canada
基金
英国医学研究理事会;
关键词
D O I
10.1038/12168
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Transmembrane and secreted glycoproteins of the semaphorin family are typically classified as inhibitory neuronal guidance molecules. However, although chemorepulsive activity has been demonstrated for several semaphorin family members, little is known about the function of the numerous transmembrane semaphorins identified to date. Here we demonstrated that the extracellular semaphorin domain of a transmembrane semaphorin, semaphorin-1a, could actively perturb axon pathfinding in vivo when presented homogenously as a recombinant freely soluble factor. When ectopic overexpression was limited to defined epithelial regions, semaphorin-1a could directly steer axons by acting as an attractive guidance molecule.
引用
收藏
页码:798 / 803
页数:6
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