Neuraminidase inhibitors as antivirals

被引：18

作者：

Colman, PM ^{[1
]}

机构：

[1] PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

来源：

VACCINE | 2002年 / 20卷

关键词：

neuraminidase; antivirals; influenza virus;

D O I：

10.1016/S0264-410X(02)00132-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The description of the three-dimensional structure of the influenza virus neuraminidase in 1983 opened a new phase in the search for inhibitors of the enzyme. Two compounds in late development (February 1999) have similar levels of potency against influenza A viruses, different routes of administration and, surprisingly, different resistance profiles both in vitro and in vivo. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：S55 / S58

页数：4

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