Stromal Cell Expression of Caveolin-1 Predicts Outcome in Breast Cancer

被引:175
作者
Sloan, Erica K. [1 ]
Ciocca, Daniel R. [2 ,3 ]
Pouliot, Normand [1 ,4 ]
Natoli, Anthony [1 ]
Restall, Christina [1 ]
Henderson, Michael A. [1 ,5 ]
Fanelli, Mariel A. [2 ,3 ]
Cuello-Carrion, Fernando D. [2 ,3 ]
Gago, Francisco E. [6 ]
Anderson, Robin L. [1 ,4 ]
机构
[1] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia
[2] Inst Expt Biol Cuyo, Mendoza, Argentina
[3] Argentina Fdn Canc Res, Mendoza, Argentina
[4] Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia
[5] Univ Melbourne, Dept Surg, Parkville, Vic 3052, Australia
[6] Natl Univ Cuyo, Dept Gynecol, Mendoza, Argentina
关键词
BASAL-LIKE; PROGESTERONE-RECEPTORS; ELEVATED EXPRESSION; IN-VIVO; GENE; PROTEIN; LINES; OVEREXPRESSION; METASTASIS; CARCINOMA;
D O I
10.2353/ajpath.2009.080924
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Caveolin-1 has been linked to tumor progression and clinical outcome in breast cancer, but a clear resolution of its role as a prognostic marker is lacking. We assessed caveolin-1 levels in normal breast tissue and two breast cancer cohorts for which outcome data were available. We found that caveolin-1 was not expressed in normal breast luminal epithelium but was present in the epithelial compartment of some tumors. We found no association between caveolin-1 expression in the epithelial compartment and clinical outcome. However, high levels of caveolin-1 in the stromal tissue surrounding the tumor, rather than within tumor cells, associated strongly with reduced metastasis and improved survival (P < 0.0001). The onset of mammary tumors driven by Her2/neu overexpression was accelerated in mice lacking caveolin-1, thereby supporting the observation that the presence of caveolin-1 in the tumor microenvironment modulates tumor development. These studies suggest that stromal caveolin-1 expression may be a potential therapeutic target and a valuable prognostic indicator of breast cancer progression. (Ant J Pathol 2009, 174:2035-2043; DOI:10.2353/ajpath.2009.080924)
引用
收藏
页码:2035 / 2043
页数:9
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