Decreased ability of rat temporal hippocampal CA1 region to produce long-term potentiation

被引:101
作者
Papatheodoropoulos, C [1 ]
Kostopoulos, G [1 ]
机构
[1] Univ Patras, Dept Physiol, Sch Med, GR-26110 Patras, Greece
关键词
septotemporal; ventral hippocampus; long-term potentiation; synaptic plasticity; memory;
D O I
10.1016/S0304-3940(99)01002-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Tetanic stimulation of Schaffer collaterals in the CA1 region of transverse slices, taken from the septal (dorsal) part of young rat hippocampus, produced N-Methyl-D-aspartate-dependent long-term potentiation (LTP) of the rising slope of excitatory postsynaptic potential (mean 38%). Under identical conditions of stimulation (100 Hz, 1 s) slices taken from the temporal (ventral) third of hippocampus presented a substantially reduced ability for LTP (mean 5%). The defect appeared to lie with the induction rather than the maintenance phase of LTP. These results suggest that a significant functional differentiation at the local synaptic plasticity level occurs between the two poles of hippocampus, which together with the substantial differences in their extrinsic connections, may help explain the reported differential participation of neutrons in these parts of hippocampus during animal memory tests. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:177 / 180
页数:4
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