BLUF: a novel FAD-binding domain involved in sensory transduction in microorganisms

被引：347

作者：

Gomelsky, M ^{[1
]}

Klug, G

机构：

[1] Univ Wyoming, Dept Mol Biol, Laramie, WY 82071 USA

[2] Univ Giessen, Inst Mikrobiol & Mol Biol, D-35392 Giessen, Germany

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 10期

关键词：

D O I：

10.1016/S0968-0004(02)02181-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel FAD-binding domain, BLUE exemplified by the N-terminus of the AppA protein from Rhodobacter sphaeroides, is present in various proteins, primarily from Bacteria. The BLUF domain is involved in sensing blue-light (and possibly redox) using FAD and is similar to the flavin-binding PAS domains and cryptochromes. The predicted secondary structure reveals that the BLUF domain is a novel FAD-binding fold.

引用

页码：497 / 500

页数：4

共 35 条

[1] Cell cycle-dependent degradation of a flagellar motor component requires a novel-type response regulator
Aldridge, P
Jenal, U
[J]. MOLECULAR MICROBIOLOGY, 1999, 32 (02) : 379 - 391
[2] CYCLIC DIGUANYLIC ACID AND CELLULOSE SYNTHESIS IN AGROBACTERIUM-TUMEFACIENS
AMIKAM, D
BENZIMAN, M
[J]. JOURNAL OF BACTERIOLOGY, 1989, 171 (12) : 6649 - 6655
[3] The GAF domain: an evolutionary link between diverse phototransducing proteins
Aravind, L
Ponting, CP
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (12) : 458 - 459
[4] Ausmees N, 2001, FEMS MICROBIOL LETT, V204, P163, DOI 10.1111/j.1574-6968.2001.tb10880.x
[5] COMPLETE CHEMICAL-STRUCTURE OF PHOTOACTIVE YELLOW PROTEIN - NOVEL THIOESTER-LINKED 4-HYDROXYCINNAMYL CHROMOPHORE AND PHOTOCYCLE CHEMIST
BACA, M
BORGSTAHL, GEO
BOISSINOT, M
BURKE, PM
WILLIAMS, DR
SLATER, KA
GETZOFF, ED
[J]. BIOCHEMISTRY, 1994, 33 (48) : 14369 - 14377
[6] Roles in dimerization and blue light photoresponse of the PAS and LOV domains of Neurospora crassa white collar proteins
Ballario, P
Talora, C
Galli, D
Linden, H
Macino, G
[J]. MOLECULAR MICROBIOLOGY, 1998, 29 (03) : 719 - 729
[7] Bateman A, 2004, NUCLEIC ACIDS RES, V32, pD138, DOI [10.1093/nar/gkp985, 10.1093/nar/gkh121, 10.1093/nar/gkr1065]
[8] Domain organization and flavin adenine dinucleotide-binding determinants in the aerotaxis signal transducer Aer of Escherichia coli
Bibikov, SI
Barnes, LA
Gitin, Y
Parkinson, JS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (11) : 5830 - 5835
[9] A single flavoprotein, AppA, integrates both redox and light signals in Rhodobacter sphaeroides
Braatsch, S
Gomelsky, M
Kuphal, S
Klug, G
[J]. MOLECULAR MICROBIOLOGY, 2002, 45 (03) : 827 - 836
[10] Phosphodiesterase A1, a regulator of cellulose synthesis in Acetobacter xylinum, is a heme-based sensor
Chang, AL
Tuckerman, JR
Gonzalez, G
Mayer, R
Weinhouse, H
Volman, G
Amikam, D
Benziman, M
Gilles-Gonzalez, MA
[J]. BIOCHEMISTRY, 2001, 40 (12) : 3420 - 3426

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