C4d and/or immunoglobulins deposition in peritubular capillaries in perioperative graft biopsies in ABO-incompatible renal transplantation

被引：25

作者：

Kanetsuna, Y

Yamaguchi, Y

Horita, S

Tanabe, K

Toma, H

机构：

[1] Jikei Univ, Dept Pathol, Minato Ku, Tokyo 1058461, Japan

[2] Jikei Univ, Kashiwa Hosp, Dept Pathol, Tokyo, Japan

[3] Tokyo Womens Med Univ, Kidney Ctr, Tokyo, Japan

[4] Tokyo Womens Med Univ, Dept Urol, Tokyo, Japan

来源：

CLINICAL TRANSPLANTATION | 2004年 / 18卷

关键词：

ABO-incompatible; acute rejection; C4d; 1 h biopsy; renal transplantation;

D O I：

10.1111/j.1399-0012.2004.00241

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

We evaluated 0 h and/or 1 h graft biopsy specimens from 14 recipients in ABO-incompatible renal transplantation using immunofluorescence for C4d, IgG, and IgM. All 0 h biopsy specimens revealed negative C4d, IgG, and IgM deposition in peritubular capillaries (PTC). In contrast, 8 of 14 1 h biopsy specimens revealed a positive C4d deposition in PTC. Eight specimens revealed positive IgM staining and seven of them had both C4d and IgM depositions. Three specimens had C4d, IgM, and IgG depositions in PTC. Three of eight patients with C4d deposition and two of six patients without C4d deposition in the 1 h biopsy group suffered from acute rejection within 1 month of transplantation. These findings suggest that complement fragments and immunoglobulin deposition in PTC in ABO-incompatible renal grafts can start soon after reperfusion, although acute rejection may or may not develop.

引用

页码：13 / 17

页数：5

共 4 条

[1]

APRK WD, 2003, AM J TRANSPLANT, V3, P952

[2] CAPILLARY DEPOSITION OF C4D COMPLEMENT FRAGMENT AND EARLY RENAL GRAFT LOSS [J].