Vascular Effects of Flavonoids

被引：10

作者：

Rezende, Bruno Almeida ^{[1
,2
]}

Pereira, Aline Carvalho ^{[1
]}

Cortes, Steyner F. ^{[3
]}

Lemos, Virginia Soares ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Physiol & Biophys, Inst Biol Sci, BR-31270901 Belo Horizonte, MG, Brazil

[2] Fac Ciencias Med, Postgrad Inst, BR-30130110 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Inst Biol Sci, Dept Pharmacol, BR-31270901 Belo Horizonte, MG, Brazil

来源：

CURRENT MEDICINAL CHEMISTRY | 2016年 / 23卷 / 01期

关键词：

Cardiovascular system; flavonoids; mechanism; natural products; signaling pathway; vascular effects; vasorelaxation; ENDOTHELIUM-DEPENDENT RELAXATION; REDUCES BLOOD-PRESSURE; PORCINE CORONARY-ARTERIES; EDHF-MEDIATED RELAXATIONS; NADPH OXIDASE ACTIVITY; GREEN TEA POLYPHENOL; SMOOTH-MUSCLE-CELLS; NITRIC-OXIDE; RED WINE; OXIDATIVE STRESS;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Flavonoids are natural plant-derived polyphenolic compounds with various biological properties particularly in the cardiovascular system, including antiatherogenic, antioxidant, vasodilation, antihypertensive, and antiplatelet activities. These biological properties have been evaluated in several experimental and clinical studies. In addition, extensive reviews have discussed the antiatherogenic effect of these polyphenols. However, limited studies have investigated the potential therapeutic vascular effects of these compounds. This review brings together some recent studies, to establish the different signaling pathways involved in the molecular mechanisms that underlie the vasodilation induced by flavonoids.

引用

收藏

页码：87 / 102

页数：16

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