Polymorphism of alcohol dehydrogenase genes in alcoholic and nonalcoholic individuals from Valencia (Spain)

被引:19
作者
Espinos, C [1 ]
Sanchez, F [1 ]
Ramirez, C [1 ]
Juan, F [1 ]
Najera, C [1 ]
机构
[1] UNIV VALENCIA, FAC CIENCIAS BIOL, DEPT GENET, VALENCIA, SPAIN
关键词
D O I
10.1111/j.1601-5223.1997.00247.x
中图分类号
Q3 [遗传学];
学科分类号
071007 [遗传学]; 090102 [作物遗传育种];
摘要
Polymorphisms in the two variable ADH loci (ADH2 and ADH3) were analyzed in two groups (alcoholics and nonalcoholics) from a Spanish population. The frequencies were similar to those reported for other Causcasian groups. ADH2-1 and ADH3-1 genotypes were more frequent in alcoholics than in nonalcoholics, but the differences were not significant.
引用
收藏
页码:247 / 253
页数:7
相关论文
共 38 条
[1]
A SEARCH FOR THE INDIANAPOLIS-VARIANT OF HUMAN ALCOHOL-DEHYDROGENASE IN LIVER AUTOPSY SAMPLES FROM NORTH GERMANY AND JAPAN [J].
AGARWAL, DP ;
MEIERTACKMANN, D ;
HARADA, S ;
GOEDDE, HW .
HUMAN GENETICS, 1981, 59 (02) :170-171
[2]
Bosron W F, 1981, Semin Liver Dis, V1, P179, DOI 10.1055/s-2008-1041746
[3]
GENETIC-POLYMORPHISM OF HUMAN-LIVER ALCOHOL AND ALDEHYDE DEHYDROGENASES, AND THEIR RELATIONSHIP TO ALCOHOL METABOLISM AND ALCOHOLISM [J].
BOSRON, WF ;
LI, TK .
HEPATOLOGY, 1986, 6 (03) :502-510
[4]
HUMAN-LIVER ALCOHOL-DEHYDROGENASE - ADHINDIANAPOLIS RESULTS FROM GENETIC-POLYMORPHISM AT THE ADH2 GENE LOCUS [J].
BOSRON, WF ;
MAGNES, LJ ;
LI, TK .
BIOCHEMICAL GENETICS, 1983, 21 (7-8) :735-744
[5]
CATALYTIC PROPERTIES OF HUMAN-LIVER ALCOHOL-DEHYDROGENASE ISOENZYMES [J].
BOSRON, WF ;
LI, TK .
ENZYME, 1987, 37 (1-2) :19-28
[6]
THE HUMAN BETA-3 ALCOHOL-DEHYDROGENASE SUBUNIT DIFFERS FROM BETA-1 BY A CYS FOR ARG-369 SUBSTITUTION WHICH DECREASES NAD(H) BINDING [J].
BURNELL, JC ;
CARR, LG ;
DWULET, FE ;
EDENBERG, HJ ;
LI, TK ;
BOSRON, WF .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 146 (03) :1227-1233
[7]
POLYMORPHISM OF ALCOHOL AND ALDEHYDE DEHYDROGENASE GENES AND ALCOHOLIC CIRRHOSIS IN CHINESE PATIENTS [J].
CHAO, YC ;
LIOU, SR ;
CHUNG, YY ;
TANG, HS ;
HSU, CT ;
LI, TK ;
YIN, SJ .
HEPATOLOGY, 1994, 19 (02) :360-366
[8]
CLONINGER C R, 1987, P47
[9]
DUESTER G, 1986, J BIOL CHEM, V261, P2027