Double strand break (DSB) repair in heterochromatin and heterochromatin proteins in DSB repair

被引：47

作者：

Lemaitre, Charlene ^{[1
]}

Soutoglou, Evi ^{[1
]}

机构：

[1] INSERM, CNRS, UdS, IGBMC,UMR 7104,U964, F-67404 Illkirch Graffenstaden, France

来源：

DNA REPAIR | 2014年 / 19卷

关键词：

DSB; DNA repair; DDR; Heterochromatin; HP1; KAP1; DNA-DAMAGE RESPONSE; REGULATES HETEROCHROMATIN; KAP-1; PHOSPHORYLATION; HP1-BETA MOBILIZATION; CHROMATIN RELAXATION; HP1; PROTEINS; ATM; RECRUITMENT; TRANSCRIPTION; LOCALIZATION;

D O I：

10.1016/j.dnarep.2014.03.015

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chromosomal translocations are a hallmark of cancer cells and they represent a major cause of tumorigenesis. To avoid chromosomal translocations, faithful repair of DNA double strand breaks (DSBs) has to be ensured in the context of high ordered chromatin structure. However, chromatin compaction is proposed to represent a barrier for DSB repair. Here we review the different mechanisms cells use to alleviate the heterochromatic barrier for DNA repair. At the same time, we discuss the activating role of heterochromatin-associated proteins in this process, therefore proposing that chromatin structure, more than being a simple barrier, is a key modulator of DNA repair. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：163 / 168

页数：6

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