Activation of second messenger pathways in alveolar macrophages by endotoxin

被引:40
作者
Monick, MM
Hunninghake, GW
机构
[1] Univ Iowa, Coll Med, Dept Med, Iowa City, IA USA
[2] Vet Adm Med Ctr, Iowa City, IA USA
关键词
endotoxin; macrophage; mitogen-activated protein kinase; nuclear factor-kappa B; phosphatidylinositol; 3-kinase; sphingolipids;
D O I
10.1183/09031936.02.00252001
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
The alveolar macrophage plays an important role in immune surveillance of the lung. Early responses to infectious agents by macrophages can decrease tissue injury and promote recovery of the host. Macrophage responses to pathogens are the cornerstone of the innate or nonspecific immune system. In particular, the response of macrophages to endotoxin from Gram negative bacteria has been the focus of many recent studies. The recent discovery of the endotoxin receptor has accelerated the study of signalling in macrophages. This review focuses on the downstream events that occur following exposure of the alveolar macrophage to endotoxin.
引用
收藏
页码:210 / 222
页数:13
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