Polysaccharide-block-polypeptide Copolymer Vesicles: Towards Synthetic Viral Capsids

被引：263

作者：

Schatz, Christophe ^{[1
,2
]}

Louguet, Stephanie ^{[1
,2
]}

Le Meins, Jean-Francois ^{[1
,2
]}

Lecommandoux, Sebastien ^{[1
,2
]}

机构：

[1] Univ Bordeaux, ENSCPB, F-33607 Pessac, France

[2] CNRS, UMR5629, Lab Chim Polymeres Organ, Pessac, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 14期

关键词：

click chemistry; polymersomes; polypeptides; polysaccharides; self-assembly; STIMULI-RESPONSIVE VESICLES; DIBLOCK COPOLYMERS; POLYMER VESICLES; POLYSTYRENE; DEXTRAN; WATER; OLIGOSACCHARIDE; COPOLYPEPTIDES; AGGREGATION; DIFFUSION;

D O I：

10.1002/anie.200805895

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Natural inspiration: Amphiphilic polysaccharide-blockpolypeptide copolymers were synthesized by click chemistry from dextran end-functionalized with an alkyne group and poly(γ-benzyl L-glutamate) end-functionalized with an azide group. The ability of these copolymers to selfassemble into small vesicles (see picture) suggests the possibility of a new generation of drug- and gene-delivery systems whose structure mimics that of viruses. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2572 / 2575

页数：4

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