Breaking down the blood-brain barrier: signaling a path to cerebral malaria?

被引:93
作者
Adams, S [1 ]
Brown, H
Turner, G
机构
[1] John Radcliffe Hosp, Nuffield Dept Clin Lab Sci, Malaria Res Grp, Oxford OX3 9DU, England
[2] John Radcliffe Hosp, Oxford Wellcome Ctr Trop & Infect Dis, Oxford OX3 9DU, England
[3] Univ Sussex, Inst Dev Studies, Brighton BN1 9RE, E Sussex, England
基金
英国惠康基金;
关键词
D O I
10.1016/S1471-4922(02)02353-X
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Cerebral malaria is a major killer in the developing world, but we still know very little about the causes of this disease. How does Plasmodium falciparum cause such a devastating neurological disease while it is in the brain vasculature? Why do some patients die, whereas others survive? What processes contribute to disease in the brain, and can we reverse them? Here, the latest evidence from post-mortem, in vitro and animal studies is reviewed to highlight the role of blood-brain barrier breakdown in cerebral malaria. Blood-brain barrier integrity is disturbed during severe malaria, causing leakage of cerebral vessels. Understanding how this happens and how it contributes to the pathogenesis of coma may provide new opportunities for the treatment of cerebral malaria.
引用
收藏
页码:360 / 366
页数:7
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