Fabrication of porous chitosan/hydroxyapatite nanocomposites: Their mechanical and biological properties

被引：45

作者：

Kashiwazaki, Haruhiko ^{[1
]}

Kishiya, Yusuke

Matsuda, Atsushi ^{[2
]}

Yamaguchi, Keisuke

Iizuka, Tadashi ^{[3
]}

Tanaka, Junzo ^{[4
]}

Inoue, Nobuo

机构：

[1] Hokkaido Univ, Grad Sch Dent Med, Dept Oral Hlth Sci, Kita Ku, Sapporo, Hokkaido 0608586, Japan

[2] KBSEIREN Ltd, Ctr Res & Dev, Fukui, Japan

[3] Hokkaido Univ, Grad Sch Dent Med, Support Sect Educ & Res, Sapporo, Hokkaido 0608586, Japan

[4] Tokyo Inst Technol, Dept Inorgan Mat, Tokyo 152, Japan

来源：

BIO-MEDICAL MATERIALS AND ENGINEERING | 2009年 / 19卷 / 2-3期

关键词：

Chitosan; hydroxyapatite (HAp); scaffold; porosity; biocompatibility; biodegradation; BONE INGROWTH; CHITOSAN; BIODEGRADATION;

D O I：

10.3233/BME-2009-0572

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

We fabricated novel chitosan/hydroxyapatite (HAp) nanocomposites with porous structure by the co-precipitation and porogen leaching method. SEM observation confirmed that the porous chitosan/HAp nanocomposites with 60.6% and 87.1% porosity showed the interconnective pores with pore diameters in the range of 100-200 mu m. The composites were found to be mechanically flexible and could be easily formed into any desired shape. The mechanical strength was enhanced by the heat treatment with saturated steam, which was ascribed to the formation of hydrogen bonds between chitosan molecules. The composites subcutaneously implanted in the backs of SD rats for 3 weeks caused little inflammation, and new blood vessel growth and giant cells were found around the composite accompanied with roughening of the surface due to degradation, showing good biocompatibility and biodegradation.

引用

页码：133 / 140

页数：8

共 19 条

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Biodegradation behavior of ultra-high-strength hydroxyapatite/poly (L-lactide) composite rods for internal fixation of bone fractures [J].