Cytotoxic triterpenes from Crataegus pinnatifida

被引：68

作者：

Min, BS

Kim, YH

Lee, SM

Jung, HJ

Lee, JS

Na, MK

Lee, CO

Lee, JP

Bae, K ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Korea Food & Drug Adm, Nat Med Prod Div, Seoul 122704, South Korea

[3] Korea Res Inst Chem & Technol, Taejon 305606, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2000年 / 23卷 / 02期

关键词：

Crataegus pinnatifida; Rosaceae; uvaol; ursolic acid; 3-oxo-ursolic acid; cytotoxicity;

D O I：

10.1007/BF02975505

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bioassay-guided fractionation of Crataegus pinnatifida (Rosaceae) gave two cytotoxic ursane-type triterpenes which were identified as uvaol (1) and ursolic acid (2) by physicochemical and spectroscopic methods. 3-Oxo-ursolic acid (3) was synthesized from ursolic acid (2) by Jones method. The cytotoxic activities of these compounds were tested against murine L1210 and human cancer cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15) in vitro. Compounds 1 and 2 showed moderate cytotoxicities against L1210, whereas they showed weak activities against human cancer cell lines. However, compound 3 exhibited potent cytotoxic activities both in murine and in human cancer cell lines.

引用

页码：155 / 158

页数：4

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