Generation of 3-pyridyl biaryl systems via palladium-catalyzed Suzuki cross-couplings of aryl halides with 3-pyridylboroxin

被引：53

作者：

Cioffi, CL ^{[1
]}

Spencer, WT ^{[1
]}

Richards, JJ ^{[1
]}

Herr, RJ ^{[1
]}

机构：

[1] Albany Mol Res Inc, Dept Med Chem, Albany, NY 12212 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 06期

关键词：

D O I：

10.1021/jo034664d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 3-pyridyl biaryl systems can be readily achieved by means of palladium-catalyzed Suzuki cross-coupling reactions between aryl halides and 3-pyridyl-boroxin. A series of cross-couplings were conducted in order to investigate the scope and limitations of this protocol.

引用

页码：2210 / 2212

页数：3

共 44 条

[1] AVENT AG, 1990, HETEROATOM CHEMISTRY /, P275
[2] BOROXINE - A SIMPLIFIED PREPARATION
BARTON, L
GRIMM, FA
PORTER, RF
[J]. INORGANIC CHEMISTRY, 1966, 5 (11) : 2076 - &
[3] Bauer S. H., 1941, J AM CHEM SOC, V63, P1394, DOI 10.1021/ja01850a075
[4] COOPERATIVE EFFECTS IN THE PHASE-TRANSFORMATION OF TRIETHYLCYCLOTRIBOROXANE
BOESE, R
POLK, M
BLASER, D
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1987, 26 (03): : 245 - 247
[5] BRACHER F, 1992, LIEBIGS ANN CHEM, P1315
[6] ORGANOBORANES .39. CONVENIENT PROCEDURES FOR THE PREPARATION OF METHYLBORONIC ACID AND TRIMETHYLBOROXIN
BROWN, HC
COLE, TE
[J]. ORGANOMETALLICS, 1985, 4 (05) : 816 - 821
[7] BROWN HC, 1979, SYNTHESIS-STUTTGART, P704
[8] Effective lithiation of 3-bromopyridine: synthesis of 3-pyridine boronic acid and variously 3-substituted pyridines
Cai, D
Larsen, RD
Reider, PJ
[J]. TETRAHEDRON LETTERS, 2002, 43 (23) : 4285 - 4287
[9] MOLECULAR STRUCTURE OF BOROXINE, H3B3O3, DETERMINED BY ELECTRON DIFFRACTION
CHANG, CH
PORTER, RF
BAUER, SH
[J]. INORGANIC CHEMISTRY, 1969, 8 (08) : 1689 - &
[10] REVISED STRUCTURE AND CONVERGENT SYNTHESIS OF NEMERTELLINE, THE NEUROTOXIC QUATERPYRIDINE ISOLATED FROM THE HOPLONEMERTINE SEA WORM
CRUSKIE, MP
ZOLTEWICZ, JA
ABBOUD, KA
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (23) : 7491 - 7495

← 1 2 3 4 5 →