PDGF receptor signaling networks in normal and cancer cells

被引：216

作者：

Demoulin, Jean-Baptiste ^{[1
]}

Essaghir, Ahmed ^{[1
]}

机构：

[1] Catholic Univ Louvain, De Duve Inst, MEXP,B1-74-05,Ave Hippocrate 75, BE-1200 Brussels, Belgium

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2014年 / 25卷 / 03期

关键词：

PDGFRA; PDGFRB; Receptor tyrosine kinase; Myeloproliferative neoplasms; Oncogenes; GROWTH-FACTOR-RECEPTOR; FACTOR-BETA-RECEPTOR; SMOOTH-MUSCLE-CELLS; NF-KAPPA-B; EXCHANGER REGULATORY FACTOR; ACTIVATED PROTEIN-KINASES; SRC FAMILY KINASES; C-MYC EXPRESSION; TISSUE-PLASMINOGEN ACTIVATOR; HEPATIC STELLATE CELLS;

D O I：

10.1016/j.cytogfr.2014.03.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

For about four decades, platelet-derived growth factors (PDGF) and their receptors have been the subject of intense research, revealing their roles in embryo development and human diseases. Drugs such as imatinib, which selectively inhibit the tyrosine kinase activity of these receptors, have been approved for the treatment of cancers such as gastrointestinal stromal tumors and chronic eosinophilic leukemia. Today, the interest in these factors is still increasing in relationship with new potential clinical applications in cancer, stroke, fibrosis and infectious diseases. This review focuses on the mechanisms of PDGF receptor signaling, with an emphasis on pathways that are important for disease development. Of particular interest, recent studies revealed significant differences between normal and cancer cells regarding signal transduction by these growth factors. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：273 / 283

页数：11

共 160 条

[1]

Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia [J].