Engagement of ICAM-3 provides a costimulatory signal for human immunodeficiency virus type 1 replication in both activated and quiescent CD4+ T lymphocytes:: Implications for virus pathogenesis

被引：4

作者：

Barat, C

Gervais, P

Tremblay, MJ

机构：

[1] CHU Laval, Res Ctr, Res Ctr Infect Dis, Lab Human Immunoretrovirol, Quebec City, PQ G1V 4G2, Canada

[2] Univ Laval, Fac Med, Quebec City, PQ G1K 7P4, Canada

来源：

JOURNAL OF VIROLOGY | 2004年 / 78卷 / 12期

关键词：

D O I：

10.1128/JVI.78.12.6692-6697.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human immunodeficiency virus type 1 (HIV-1) replication is regulated by several extracellular signals. We demonstrate that intercellular adhesion molecule 3 (ICAM-3) acts as a costimulating molecule to increase HIV-1 transcription and viral production, a process allowing productive infection of quiescent CD4(+) T lymphocytes. The present work suggests an important role for ICAM-3 in HIV-1 replication.

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页码：6692 / 6697

页数：6

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