Salivary duct carcinoma arising in IgG4-related autoimmune disease of the parotid gland

被引：57

作者：

Gill, Jespal ^{[1
]}

Angelo, Neville ^{[1
]}

Yeong, Mee Ling ^{[1
]}

McIvor, Nick ^{[2
]}

机构：

[1] Diagnost Medlab, Auckland 1060, New Zealand

[2] Auckland City Hosp, Auckland 1023, New Zealand

来源：

HUMAN PATHOLOGY | 2009年 / 40卷 / 06期

关键词：

Hyper IgG4 disease; IgG4-related sclerosing disease; Autoimmune disease; Salivary duct carcinoma; Chronic sclerosing sialadenitis; Plasma cells; Fibrosis; SCLEROSING PANCREATITIS; IGG4; RETROPERITONEAL; EXPRESSION; FIBROSIS; CANCER; CELL;

D O I：

10.1016/j.humpath.2008.10.020

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Hyper IgG4 disease or IgG4-related sclerosing/autoimmune disease is a multisystem condition characterized histologically by fibrosis, lymphoplasmacytic infiltration, and abundant IgG4 plasma cells associated with raised serum IgG4 levels. We present a case of salivary duct carcinoma of the parotid gland in a background of chronic sclerosing sialadenitis that also involved the submandibular gland with associated regional lymphadenopathy. The serology showed raised total IgG levels of 16.3 g/L (reference range, 6.0-15.0) and raised IgG4 levels of 3.41 g/L (reference range, 0.07-1.70). The salivary duct carcinoma contained areas of dense fibrosis and abundant IgG4-positive plasma cells (>100 per high-power field [hpf]). The adjacent noncarcinomatous areas, submandibular gland, and regional lymph nodes also contained plasma cells immunoreactive to IgG4 with densities higher than 100/hpf. To the best of our knowledge, this case is the first documentation of malignancy occurring in a background of IgG4-related autoimmune disease of the salivary gland. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：881 / 886

页数：6

共 15 条

[1] Ocular adnexal lymphoma associated with IgG4+chronic sclerosing dacryoadenitis: A previously undescribed complication of IgG4-related sclerosing disease [J].