Climacostol, a defense toxin of Climacostomum virens (protozoa, ciliata), and its congeners

被引：24

作者：

Masaki, ME

Hiro, S

Usuki, Y

Harumoto, T

Terazima, MN

Buonanno, F

Miyake, A

Iio, H ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Sci, Dept Mat Sci, Osaka 5588585, Japan

[2] Nara Womens Univ, Grad Sch, Nara 6308506, Japan

[3] Univ Camerino, Dept Mol Cellular & Anim Biol, I-62032 Camerino, MC, Italy

来源：

TETRAHEDRON | 2004年 / 60卷 / 33期

关键词：

biologically active compounds; toxins; phenols; resorcinol; cobalt compounds;

D O I：

10.1016/j.tet.2003.09.105

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Climacostol (1), a defense toxin of the heterotrich ciliate Climacostomum virens was established as 5-(Z)-non-2-enyl-benzene-1,3-diol. The structure was rigorously confirmed by the total synthesis. The two congeners of climacostol contained in this ciliate were determined as 5-(Z,Z)-undeca-2,5-dienyl-benzene-1,3-diol (2) and 5-(Z,Z,Z)-undeca-2,5,8-trienyl-benzene-1,3-diol (3). (C) 2004 Elsevier Ltd. All rights reserved.

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页码：7041 / 7048

页数：8

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