Herbacic acid, a simple prototype of 5,5,5-trichloroleucine metabolites from the sponge Dysidea herbacea

被引：33

作者：

MacMillan, JB ^{[1
]}

Molinski, TF ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 01期

关键词：

D O I：

10.1021/np990468j

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Dysidea herbacea, collected at Harrier Reef on the Great Barrier Reef, contains the novel metabolite herbacic acid as the major trichloroleucine metabolite. Herbacic acid appears to be an early product of direct free-radical chlorination of leucine and is a prototype for further transformation of the free carboxylic acid group and generation of complex trichloromethyl metabolites, including natural products of the dysidenin family.

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页码：155 / 157

页数：3

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