In vivo neurochemical monitoring by microdialysis and capillary separations

被引：88

作者：

Kennedy, RT

Watson, CJ

Haskins, WE

Powell, DH

Strecker, RE

机构：

[1] Univ Michigan, Dept Chem & Pharmacol, Ann Arbor, MI 48109 USA

[2] Harvard Med Sch, Brockton, MA 02301 USA

[3] VA Med Ctr, Brockton, MA 02301 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 05期

关键词：

D O I：

10.1016/S1367-5931(02)00373-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microdialysis is valuable for studying the neurochemical changes underlying behavior. Recent advances include the application of the high-sensitivity methods of capillary electrophoresis and capillary liquid chromatography with mass spectrometry to dialysate analysis, These methods have improved temporal resolution, spatial resolution, multi-analyte capability and potential for compound discovery.

引用

页码：659 / 665

页数：7

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