The long-term effect of dietary advice in men with coronary disease: follow-up of the Diet and Reinfarction trial (DART)

被引:79
作者
Ness, AR
Hughes, J
Elwood, PC
Whitley, E
Smith, GD
Burr, ML
机构
[1] Univ Bristol, Dept Social Med, Bristol BS8 2PR, Avon, England
[2] Llandough Hosp, MRC, Epidemiol Unit S Wales, Penarth, S Glam, Wales
[3] Univ Wales Coll Cardiff, Coll Med, Ctr Appl Publ Hlth Med, Cardiff CF1 3NS, S Glam, Wales
关键词
fish; fibre; fat; dietary advice; randomised controlled trial; all-cause mortality; coronary heart disease; stroke;
D O I
10.1038/sj.ejcn.1601342
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objective: To assess the long-term effect of dietary advice on diet and mortality after a randomised trial of men with a recent history of myocardial infarction. Design: Questionnaire survey and mortality follow-up after a trial of dietary advice. Setting: Twenty-one hospitals in south Wales and south-west England. Subjects: Former participants in the Diet and Reinfarction Trial. Main outcome measures: Current fish intake and cereal fibre intake. All-cause mortality, stroke mortality and coronary mortality. Results: By February 2000, after 21 147 person years of follow-up, 1083 (53%) of the men had died. Completed questionnaires were obtained from 879 (85%) of the 1030 men alive at the beginning of 1999. Relative increases in fish and fibre intake were still present at 10 y but were much smaller. The early reduction in all-cause mortality observed in those given fish advice (unadjusted hazard 0.70 (95% Cl 0.54, 0.92)) was followed by an increased risk over the next 3 y (unadjusted hazard 1.31 (95% Cl 1.01, 1.70). Fat and fibre advice had no clear effect on coronary or all-cause mortality. The risk of stroke death was increased in the fat advice group-the overall unadjusted hazard was 2.03 (95% Cl 1.14, 3.63). Conclusions: In this follow-up of a trial of intensive dietary advice following myocardial infarction we did not observe any substantial long-term survival benefit. Further trials of fish and fibre advice are feasible and necessary to clarify the role of these foods in coronary disease.
引用
收藏
页码:512 / 518
页数:7
相关论文
共 15 条
[1]   Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas [J].
Alberts, DS ;
Martínez, ME ;
Roe, DJ ;
Guillén-Rodríguez, JM ;
Marshall, JR ;
van Leeuwen, JB ;
Reid, ME ;
Ritenbaugh, C ;
Vargas, PA ;
Bhattacharyya, AB ;
Earnest, DL ;
Sampliner, RE ;
Parish, D ;
Koonce, K ;
Fales, L .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (16) :1156-1162
[2]  
Anderson JW, 1999, AM J CLIN NUTR, V70, P307
[3]   Prevention of ischemia-induced cardiac sudden death by n-3 polyunsaturated fatty acids in dogs [J].
Billman, GE ;
Kang, JX ;
Leaf, A .
LIPIDS, 1997, 32 (11) :1161-1168
[4]   Calcium and fibre supplementation in prevention of colorectal adenoma recurrence:: a randomised intervention trial [J].
Bonithon-Kopp, C ;
Kronborg, O ;
Giacosa, A ;
Räth, U ;
Faivre, J .
LANCET, 2000, 356 (9238) :1300-1306
[5]  
BURR ML, 1989, LANCET, V2, P757
[6]   DIET AND REINFARCTION TRIAL (DART) - DESIGN, RECRUITMENT, AND COMPLIANCE [J].
BURR, ML ;
FEHILY, AM ;
ROGERS, S ;
WELSBY, E ;
KING, S ;
SANDHAM, S .
EUROPEAN HEART JOURNAL, 1989, 10 (06) :558-567
[7]  
FEHILY A M, 1989, Journal of Human Nutrition and Dietetics, V2, P225, DOI 10.1111/j.1365-277X.1989.tb00026.x
[8]   Inverse association of dietary fat with development of ischemic stroke in men [J].
Gillman, MW ;
Cupples, LA ;
Millen, BE ;
Ellison, RC ;
Wolf, PA .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (24) :2145-2150
[9]   Dietary fat intake and prevention of cardiovascular disease: systematic review [J].
Hooper, L ;
Summerbell, CD ;
Higgins, JPT ;
Thompson, RL ;
Capps, NE ;
Smith, GD ;
Riemersma, RA ;
Ebrahim, S .
BMJ-BRITISH MEDICAL JOURNAL, 2001, 322 (7289) :757-763
[10]   CHANGING PATTERNS OF CORONARY HEART-DISEASE, STROKE, AND NUTRIENT INTAKE IN JAPAN [J].
KIMURA, N .
PREVENTIVE MEDICINE, 1983, 12 (01) :222-227