Coffee inhibits the reactivation of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1:: A glucocorticoid connection in the anti-diabetic action of coffee?

被引：30

作者：

Atanasov, Atanas G. ^{[1
]}

Dzyakanchuk, Anna A. ^{[1
]}

Schweizer, Roberto A. S. ^{[1
]}

Nashev, Lyubomir G. ^{[1
]}

Maurer, Evelyne M. ^{[1
]}

Odermatt, Alex ^{[1
]}

机构：

[1] Univ Bern, Dept Clin Res, Div Nephrol & Hypertens, CH-3010 Bern, Switzerland

来源：

FEBS LETTERS | 2006年 / 580卷 / 17期

关键词：

11 beta-hydroxysteroid dehydrogenase; glucocorticoid; coffee; cortisol; diabetes;

D O I：

10.1016/j.febslet.2006.06.046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Recent epidemiological studies demonstrated a beneficial effect of coffee consumption for the prevention of type 2 diabetes, however, the underlying mechanisms remained unknown. We demonstrate that coffee extract, corresponding to an Italian Espresso, inhibits recombinant and endogenous 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) activity. The inhibitory component is heat-stable with considerable polarity. Coffee extract blocked 11 beta-HSD1-dependent cortisol formation, prevented the subsequent nuclear translocation of the glueocorticoid receptor and abolished glucocorticoid-induced expression of the key gluconeogenic enzyme phosphoenolpyruvate carboxykinase. We suggest that at least part of the anti-diabetic effects of coffee consumption is due to inhibition of 11 beta-HSD1-dependent glucocorticoid reactivation. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4081 / 4085

页数：5

共 33 条

[1]

Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains [J].

Alberts, P ;

Nilsson, C ;

Selén, G ;

Engblom, LOM ;

Edling, NHM ;

Norling, S ;

Klingström, G ;

Larsson, C ;

Forsgren, M ;

Ashkzari, M ;

Nilsson, CE ;

Fiedler, M ;

Bergqvist, E ;

Öhman, B ;

Björkstrand, E ;

Abrahmsén, LB .

ENDOCRINOLOGY, 2003, 144 (11) :4755-4762

[2]

Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice [J].

Alberts, P ;

Engblom, L ;

Edling, N ;

Forsgren, M ;

Klingström, G ;

Larsson, C ;

Rönquist-Nii, Y ;

Öhman, B ;

Abrahmsén, L .

DIABETOLOGIA, 2002, 45 (11) :1528-1532

[3]

Dehydroepiandrosterone inhibits the amplification of glucocorticoid action in adipose tissue [J].

Apostolova, G ;

Schweizer, RAS ;

Balazs, Z ;

Kostadinova, RM ;

Odermatt, A .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2005, 288 (05) :E957-E964

[4]

Comparative enzymology of 11β-hydroxysteroid dehydrogenase type 1 from six species [J].

Arampatzis, S ;

Kadereit, B ;

Schuster, D ;

Balazs, Z ;

Schweizer, RAS ;

Frey, FJ ;

Langer, T ;

Odermatt, A .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2005, 35 (01) :89-101

[5]

Role of glucocorticoids in the physiopathology of excessive fat deposition and insulin resistance [J].

Asensio, C ;

Muzzin, P ;

Rohner-Jeanrenaud, F .

INTERNATIONAL JOURNAL OF OBESITY, 2004, 28 (Suppl 4) :S45-S52

[6]

Hexose-6-phosphate dehydrogenase determines the reaction direction of 11β-hydroxysteroid dehydrogenase type 1 as an oxoreductase [J].

Atanasov, AG ;

Nashev, LG ;

Schweizer, RAS ;

Frick, C ;

Odermatt, A .

FEBS LETTERS, 2004, 571 (1-3) :129-133

[7]

The glucose intolerance induced by caffeinated coffee ingestion is less pronounced than that due to alkaloid caffeine in men [J].

Battram, DS ;

Arthur, R ;

Weekes, A ;

Graham, TE .

JOURNAL OF NUTRITION, 2006, 136 (05) :1276-1280

[8]

Beneficial role of dietary phytoestrogens in obesity and diabetes [J].

Bhathena, SJ ;

Velasquez, MT .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2002, 76 (06) :1191-1201

[9]

Evidence using a green fluorescent protein-glucocorticoid receptor chimera that the RAN/TC4 GTPase mediates an essential function independent of nuclear protein import [J].

Carey, KL ;

Richards, SA ;

Lounsbury, KM ;

Macara, IG .

JOURNAL OF CELL BIOLOGY, 1996, 133 (05) :985-996

[10]

Is coffee a functional food? [J].

Dórea, JG ;

da Costa, THM .

BRITISH JOURNAL OF NUTRITION, 2005, 93 (06) :773-782

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