Saponins isolated from the root of Platycodon grandiflorum protect against acute ethanol-induced hepatotoxicity in mice

被引：61

作者：

Khanal, Tilak ^{[1
]}

Choi, Jae Ho ^{[1
]}

Hwang, Yong Pil ^{[1
]}

Chung, Young Chul ^{[2
]}

Jeong, Hye Gwang ^{[1
]}

机构：

[1] Chosun Univ, BK Project Team 21, Dept Pharm, Coll Pharm, Kwangju 501759, South Korea

[2] Int Univ Korea, Div Food Sci, Munsan Eup 660759, Jinju, South Korea

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2009年 / 47卷 / 03期

关键词：

Platycodon grandiflorum; Ethanol; Alcoholic steatosis; Liver injury; CYP2E1; TETRACHLORIDE-INDUCED HEPATOTOXICITY; ALCOHOLIC LIVER-DISEASE; CYTOCHROME-P450; 2E1; EXPRESSION; CARBON-TETRACHLORIDE; OXIDATIVE STRESS; MITOCHONDRIAL GLUTATHIONE; LIPID-PEROXIDATION; ACID PROTECTS; INJURY; RATS;

D O I：

10.1016/j.fct.2008.12.009

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

The protective effects of saponins isolated from the root of Platycodon grandiflorum (Changkil saponins: CKS) against alcoholic steatosis in liver injury induced by acute ethanol administration were investigated. Pretreatment with CKS prior to ethanol administration significantly prevented the increases in serum alanine aminotransferase activity, hepatic TNF-alpha level, hepatic lipid peroxidation and hepatic triglyceride level. CKS prevented ethanol-induced steatosis and necrosis, as indicated by liver histopathological studies. Additionally, CKS protected against ethanol-induced depletion of hepatic glutathione levels. CYP2E1 has been suggested as a major contributor to ethanol-induced oxidative stress and liver injury. The concurrent administration of CKS efficaciously abrogated the CYP2E1 induction and CYP2E1-dependents hydroxylation of aniline as compared to the individual treatment at higher doses. These findings suggest that CKS may prevent ethanol-induced acute liver injury. possibly through its ability to block CYP2E1-mediated ethanol bioactivation and its free radical scavenging effects. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：530 / 535

页数：6

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