Facts and fallacies of blood pressure control in recent trials: implications in the management of patients with hypertension

被引：49

作者：

Zanchetti, Alberto ^{[1
,2
]}

Mancia, Giuseppe ^{[3
]}

Black, Henry R. ^{[4
]}

Oparil, Suzanne ^{[5
]}

Waeber, Bernard ^{[6
]}

Schmieder, Roland E. ^{[7
]}

Bakris, George L. ^{[8
]}

Messerli, Franz H. ^{[9
]}

Kjeldsen, Sverre E. ^{[10
]}

Ruilope, Luis M. ^{[11
]}

机构：

[1] Univ Milan, Ctr Fisiol Clin & Ipertens, I-20122 Milan, Italy

[2] Ist Auxol Italiano, Milan, Italy

[3] Univ Milano Bicocca, Osped San Gerardo, Med Clin, Monza, Italy

[4] NYU, Sch Med, New York, NY USA

[5] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[6] CHU Vaudois, Dept Med, Div Hypertens, CH-1011 Lausanne, Switzerland

[7] Univ Hosp, Dept Hypertens & Nephrol, Erlangen, Germany

[8] Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA

[9] St Lukes Roosevelt Hosp, New York, NY USA

[10] Ullevaal Univ Hosp, Dept Internal Med, Oslo, Norway

[11] Hosp 12 Octubre, Hypertens Unit, E-28041 Madrid, Spain

来源：

JOURNAL OF HYPERTENSION | 2009年 / 27卷 / 04期

关键词：

antihypertensive agents; blood pressure determination; cardiovascular diseases; hypertension; CONVERTING-ENZYME-INHIBITOR; RANDOMIZED CONTROLLED-TRIAL; CORONARY-HEART-DISEASE; RENAL-DISEASE; RECEPTOR BLOCKER; DUAL BLOCKADE; DOUBLE-BLIND; STROKE; PREVENTION; REDUCTION;

D O I：

10.1097/HJH.0b013e3283298ea2

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

A large body of clinical trial data indicates that a given difference in blood pressure (BP), as measured in the clinic, results in a given difference in outcome. This correlation underpins current US and European guidelines for the management of hypertension. However, findings from recent comparative trials may appear inconsistent with a fixed relationship between BP lowering and outcome benefit, at least at all BP ranges, at all levels of total cardiovascular risk and with all drug combinations. We review the findings of six of these recent trials and conclude that their complex design precludes a simple interpretation, that several important questions remain unanswered and that direct evidence particularly in support of lowering systolic BP below 140 or 130 mmHg - is urgently needed. J Hypertens 27:673-679 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.

引用

页码：673 / 679

页数：7

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