NAP accelerates the performance of normal rats in the water maze

被引：34

作者：

Gozes, I ^{[1
]}

Alcalay, R

Giladi, E

Pinhasov, A

Furman, S

Brenneman, DE

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Dept Clin Biochem, IL-69978 Tel Aviv, Israel

[2] NICHD, Sec Dev & Mol Pharmacol, LDN, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2002年 / 19卷 / 1-2期

关键词：

peptides; neuroprotection; middle-aged rats;

D O I：

10.1007/s12031-002-0028-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NAP (Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln) has neuroprotective, memory enhancing, and neurotrophic properties. NAP is a short peptide sequence derived from the recently cloned, activity-dependent neuroprotective protein. The current study was designed to evaluate NAP activity in normal middle-aged animals to further assess NAP's breadth of neuroprotection. NAP was administered by inhalation. Results showed that in the paradigm of the Morris water maze, assessing short-term memory, only the NAP-treated middle-aged rats and not placebo-treated rats showed significant improvements by the end of the testing period. These results suggest efficacy for NAP in normal aging that is associated with accumulating environmental and genetic toxic factors.

引用

页码：167 / 170

页数：4

共 17 条

[1] Vasoactive intestinal peptide and related molecules induce nitrite accumulation in the extracellular milieu of rat cerebral cortical cultures [J].

Ashur-Fabian, O ;

Giladi, E ;

Furman, S ;

Steingart, RA ;

Wollman, Y ;

Fridkin, M ;

Brenneman, DE ;

Gozes, I .

NEUROSCIENCE LETTERS, 2001, 307 (03) :167-170

[2] Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide [J].

Bassan, M ;

Zamostiano, R ;

Davidson, A ;

Pinhasov, A ;

Giladi, E ;

Perl, O ;

Bassan, H ;

Blat, C ;

Gibney, G ;

Glazner, G ;

Brenneman, DE ;

Gozes, I .

JOURNAL OF NEUROCHEMISTRY, 1999, 72 (03) :1283-1293

[3]

Beni-Adani L, 2001, J PHARMACOL EXP THER, V296, P57

[4] NONNEURONAL CELLS MEDIATE NEUROTROPHIC ACTION OF VASOACTIVE-INTESTINAL-PEPTIDE [J].

BRENNEMAN, DE ;

NEALE, EA ;

FOSTER, GA ;

DAUTREMONT, SW ;

WESTBROOK, GL .

JOURNAL OF CELL BIOLOGY, 1987, 104 (06) :1603-1610

[5]

Gozes I, 1999, CURR MED CHEM, V6, P1019

[6]

Gozes I, 2000, J PHARMACOL EXP THER, V293, P1091

[7]

Gozes I, 2000, ANN NY ACAD SCI, V921, P115

[8] A novel signaling molecule for neuropeptide action: Activity-dependent neuroprotective protein [J].

Gozes, I ;

Bassan, M ;

Zamostiano, R ;

Pinhasov, A ;

Davidson, A ;

Giladi, E ;

Perl, O ;

Glazner, GW ;

Brenneman, DE .

NEUROPEPTIDES: STRUCTURE AND FUNCTION IN BIOLOGY AND BEHAVIOR, 1999, 897 :125-135

[9] A new concept in the pharmacology of neuroprotection [J].

Gozes, I ;

Brenneman, DE .

JOURNAL OF MOLECULAR NEUROSCIENCE, 2000, 14 (1-2) :61-68

[10]

GOZES I, 2001, ADV DRUG DISCOVERY D, P204

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