Differing patterns of liver disease progression and hepatitis C virus (HCV) quasispecies evolution in children vertically coinfected with HCV and human immunodeficiency virus type 1

被引：21

作者：

Canobio, S

Guilbert, CM

Troesch, M

Samson, J

Lemay, M

Pelletier, VA

Bernard-Bonnin, AC

Kozielski, R

Lapointe, N

Martin, SR

Soudeyns, H

机构：

[1] Hop St Justine, Ctr Rech, Unite Immunopathol Virale, Montreal, PQ H3T 1C5, Canada

[2] Hop St Justine, Ctr Rech, Ctr Maternel & Infantile SIDA, Montreal, PQ H3T 1C5, Canada

[3] Hop St Justine, Ctr Rech, Div Gastroenterol, Montreal, PQ H3T 1C5, Canada

[4] Hop St Justine, Ctr Rech, Dept Pathol, Montreal, PQ H3T 1C5, Canada

[5] Univ Montreal, Fac Med, Dept Microbiol & Immunol, Montreal, PQ H3C 3J7, Canada

[6] Univ Montreal, Fac Med, Dept Pediat, Montreal, PQ H3C 3J7, Canada

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2004年 / 42卷 / 09期

关键词：

D O I：

10.1128/JCM.42.9.4365-4369.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis C virus (HCV) quasispeciation was studied in two children vertically coinfected with HCV and human immunodeficiency virus type 1 (HIV-1). HCV quasispecies diversification and liver injury were more significant in patient C1, who was immunocompetent with anti-HIV therapy, than in patient C2, who was immunosuppressed, in consistency with modulation of HCV quasispeciation and liver injury by immunocompetence in coinfected children.

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页码：4365 / 4369

页数：5

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