Vaginal hydrolytic enzymes, immunoglobulin A against Gardnerella vaginalis toxin, and risk of early preterm birth among women in preterm labor with bacterial vaginosis or intermediate flora

被引:46
作者
Cauci, S [1 ]
Hitti, J
Noonan, C
Agnew, K
Quadrifoglio, F
Hillier, SL
Eschenbach, DA
机构
[1] Univ Udine, Sch Med, Dept Biomed Sci & Technol, I-33100 Udine, Italy
[2] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA
[3] Univ Pittsburgh, Magee Womens Res Inst, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USA
关键词
early preterm birth; bacterial vaginosis; Gardnerella vaginalis; immunoglobulin A; sialidase; prolidase;
D O I
10.1067/mob.2002.127454
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: The purpose of this study was to determine whether the microbial hydrolytic enzymes, sialidase and prolidase, and immunoglobulin A against the Gardnerella vaginalis cytolysin (anti-Gvh IgA) increase the risk for early preterm birth (less than or equal to34 weeks of gestation) among women with bacterial vaginosis or intermediate flora. STUDY DESIGN: Two hundred eighteen afebrile women in preterm labor with intact membranes had a vaginal Gram stain performed, and sialidase, prolidase, and anti-Gvh IgA concentrations were determined. RESULTS: Women with bacterial vaginosis or intermediate flora had significantly higher sialidase and prolidase concentrations than women with normal flora. Among women with bacterial vaginosis or intermediate flora, the women with sialidase had a higher rate of early preterm birth (P =.05). Sialidase had a sensitivity of 43% and specificity of 77% for early preterm birth. Prolidase and anti-Gvh IgA did not predict early preterm birth. CONCLUSION: Women in preterm labor with bacterial vaginosis or intermediate flora and detectable sialidase are at increased risk of early preterm birth.
引用
收藏
页码:877 / 881
页数:5
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