Low blood pressure and dementia in elderly people: The Kungsholmen project

Objective-To examine the relation between blood pressure and dementia in elderly people. Design-Cross sectional, population based study. Setting-Kungsholmen district of Stockholm, Sweden. Subjects-1642 subjects aged 75-101 years. Main outcome measures-Prevalence and adjusted odds ratio of dementia by blood pressure. Results-People with systolic pressure less than or equal to 140 mmHg were more often diagnosed as demented than those with systolic pressure >140 mmHg: odds ratios (95% confidence interval) adjusted for age, sex, and education were 2.98 (2.17 to 4.08) for all dementias, 2.91 (1.93 to 4.38) for Alzheimer's disease, 2.00 (1.09 to 3.65) for vascular dementia, and 5.07 (2.65 to 9.70) for other dementias. Similar results were seen in subjects with diastolic pressure less than or equal to 75 mmHg compared with those with higher diastolic pressure. When severity and duration of dementia were taken into account, only moderate and severe dementia were found to be significantly related to relatively low blood pressure, and the association was stronger in subjects with longer disease duration. Use of hypotensive drugs and comorbidity with cardiovascular disease did not modify the results for all dementias, Alzheimer's disease, and other dementias but slightly reduced the association between vascular dementia and diastolic blood pressure. Conclusions-Both systolic and diastolic blood pressure were inversely related to prevalence of dementia in elderly people. We think that relatively low blood pressure is probably a complication of the dementia process, particularly Alzheimer's disease, although it is possible that low blood pressure may predispose a subpopulation to developing dementia.