How will genetic approaches assist in the management of respiratory diseases?

被引：4

作者：

Hall, Ian P. ^{[1
]}

机构：

[1] Univ Nottingham Hosp, Div Therapeut & Mol Med, Nottingham NG7 2UH, England

来源：

CURRENT OPINION IN PHARMACOLOGY | 2009年 / 9卷 / 03期

关键词：

1958 BIRTH COHORT; BETA(2)-ADRENERGIC RECEPTOR; POSITIONAL CLONING; CYSTIC-FIBROSIS; ASTHMA; POLYMORPHISMS; ASSOCIATION; CHILDHOOD; MUTATIONS; GENOTYPE;

D O I：

10.1016/j.coph.2009.03.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

There are a number of ways in which understanding the genetic basis of either disease pathogenesis or treatment response might be of value in the management of respiratory diseases. Although some single gene defect respiratory diseases such as cystic fibrosis exist, the majority of common respiratory diseases are caused by the interaction of multiple genes and environmental factors. Newer approaches including the use of genome wide association studies will help define the underlying genetic factors. Understanding the genetic basis for disease will throw new light on the pathophysiology of disease, may help redefine disease subtypes, and may also contribute to therapeutic approaches. The aim of this review is to assess the current state of our knowledge of these areas of research.

引用

页码：256 / 261

页数：6

共 26 条

[1] Positional cloning of a novel gene influencing asthma from Chromosome 2q14 [J].

Allen, M ;

Heinzmann, A ;

Noguchi, E ;

Abecasis, G ;

Broxholme, J ;

Ponting, CP ;

Bhattacharyya, S ;

Tinsley, J ;

Zhang, YM ;

Holt, R ;

Jones, EY ;

Lench, N ;

Carey, A ;

Jones, H ;

Dickens, NJ ;

Dimon, C ;

Nicholls, R ;

Baker, C ;

Xue, LZ ;

Townsend, E ;

Kabesch, M ;

Weiland, SK ;

Carr, D ;

von Mutius, E ;

Adcock, IM ;

Barnes, PJ ;

Lathrop, GM ;

Edwards, M ;

Moffatt, MF ;

Cookson, WOCM .

NATURE GENETICS, 2003, 35 (03) :258-263

[2] Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease [J].

Ansari, A. ;

Arenas, M. ;

Greenfield, S. M. ;

Morris, D. ;

Lindsay, J. ;

Gilshenan, K. ;

Smith, M. ;

Lewis, C. ;

Marinaki, A. ;

Duley, J. ;

Sanderson, J. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2008, 28 (08) :973-983

[3] Contribution of ADAM33 polymorphisms to the population risk of asthma [J].

Blakey, J ;

Halapi, E ;

Bjornsdottir, US ;

Wheatley, A ;

Kristinsson, S ;

Upmanyu, R ;

Stefansson, K ;

Hakonarson, H ;

Hall, IP .

THORAX, 2005, 60 (04) :274-276

[4] Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort [J].

Blakey, J. D. ;

Sayers, I. ;

Ring, S. M. ;

Strachan, D. P. ;

Hall, I. P. .

THORAX, 2009, 64 (05) :381-387

[5] Effect of ADRB2 polymorphisms on response to longacting β2-agonist therapy:: a pharmacogenetic analysis of two randomised studies [J].

Bleecker, Eugene R. ;

Postma, Dirkje S. ;

Lawrance, Rachael M. ;

Meyers, Deborah A. ;

Ambrose, Helen J. ;

Goldman, Mitch .

LANCET, 2007, 370 (9605) :2118-2125

[6] Salmeterol response is not affected by β2-adrenergic receptor genotype in subjects with persistent asthma [J].

Bleecker, Eugene R. ;

Yancey, Steven W. ;

Baitinger, Leslie A. ;

Edwards, Lisa D. ;

Klotsman, Michael ;

Anderson, Wayne H. ;

Dorinsky, Paul M. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 118 (04) :809-816

[7] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[8]

CRANE J, 1989, LANCET, V1, P917

[9] Cystic fibrosis since 1938 [J].

Davis, PB .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 173 (05) :475-482

[10] Mutations in KCNJ11, which encodes Kir6.2, are a common cause of diabetes diagnosed in the first 6 months of life, with the phenotype determined by genotype [J].

Flanagan, SE ;

Edghill, EL ;

Gloyn, AL ;

Ellard, S ;

Hattersley, AT .

DIABETOLOGIA, 2006, 49 (06) :1190-1197

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