Protection, metalation, and electrophilic substitution of 5-methyl tetrazole

被引：25

作者：

Huff, BE

LeTourneau, ME

Staszak, MA

Ward, JA

机构：

[1] Lilly Research Laboratories, Chem. Proc. Res. and Devmt., 4813, Indianapolis

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 21期

关键词：

D O I：

10.1016/0040-4039(96)00654-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Methyl tetrazole was N-protected with the trityl group and deprotonated using n-BuLi. The resulting 5-methyl anion was trapped with a variety of electrophiles to provide B-substituted tetrazoles in good yields. The trityl protecting group was readily removed using HCl in methylene chloride. Copyright (C) 1996 Elsevier Science Ltd.

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页码：3655 / 3658

页数：4

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