Tracking the Dynamics of Salmonella Specific T Cell Responses

被引：30

作者：

Moon, James J. ^{[2
,3
]}

McSorley, Stephen J. ^{[1
,2
,4
]}

机构：

[1] Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sch Med, Ctr Immunol, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Sch Med, Dept Microbiol, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Sch Med, Ctr Infect Dis & Microbiol Translat Res, Minneapolis, MN 55455 USA

来源：

VISUALIZING IMMUNITY | 2009年 / 334卷

关键词：

ENTERICA SEROVAR TYPHIMURIUM; COMPLETE GENOME SEQUENCE; MURINE HOST PROTECTION; CLASS IB MOLECULES; IN-VIVO; IMMUNE-RESPONSE; DENDRITIC CELLS; ANTIGEN PRESENTATION; TYPHOID-FEVER; IFN-GAMMA;

D O I：

10.1007/978-3-540-93864-4_8

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Over the last decade, significant advances have been made in the methodology for studying immune responses in vivo. It is now possible to follow almost every aspect of pathogen-specific immunity using in vivo models that incorporate physiological infectious doses and natural routes of infection. This new ability to study immunity in a relevant physiological context will greatly expand our understanding of the dynamic interplay between host and pathogen. Visualizing the resolution of primary infection and the development of long-term immunological memory should also aid the development of new vaccines and therapeutics for infectious diseases. In this review, we will describe the application of in vivo visualization technology to Salmonella infection, describe our current understanding of Salmonella-specific immunity, and discuss some unanswered questions that remain in this model.

引用

页码：179 / 198

页数：20

共 127 条

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