Network formation of lipid membranes: Triggering structural transitions by chain melting

被引：105

作者：

Schneider, MF

Marsh, D

Jahn, W

Kloesgen, B

Heimburg, T ^{[1
]}

机构：

[1] Max Planck Inst Biophys Chem, Membrane Thermodynam Grp, D-37070 Gottingen, Germany

[2] Max Planck Inst Biophys Chem, Dept Spect, D-37070 Gottingen, Germany

[3] Max Planck Inst Biophys Chem, Dept Membrane Biophys, D-37070 Gottingen, Germany

[4] Free Univ Berlin, Dept Phys, D-14195 Berlin, Germany

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1999年 / 96卷 / 25期

关键词：

D O I：

10.1073/pnas.96.25.14312

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Phospholipids when dispersed in excess water generally form vesicular membrane structures. Cryo-transmission and freeze-fracture electron microscopy are combined here with calorimetry and viscometry to demonstrate the reversible conversion of phosphatidylglycerol aqueous vesicle suspensions to a three-dimensional structure that consists of extended bilayer networks. Thermodynamic analysis indicates that the structural transitions arise from two effects: (i) the enhanced membrane elasticity accompanying the lipid state fluctuations on chain melting and (ii) solvent-associated interactions (including electrostatics) that favor a change in membrane curvature. The material properties of the hydrogels and their reversible formation offer the possibility of future applications, for example in drug delivery, the design of structural switches, or for understanding vesicle fusion or fission processes.

引用

页码：14312 / 14317

页数：6

共 31 条

[1] The effect of increasing membrane curvature on the phase transition and mixing behavior of a dimyristoyl-sn-glycero-3-phosphatidylcholine/distearoyl-sn-glycero-3-phosphatidylcholine lipid mixture as studied by Fourier transform infrared spectroscopy and differential scanning calorimetry [J].