Epstein-Barr virus infection of human gastric carcinoma cells: Implication of the existence of a new virus receptor different from CD21

被引：117

作者：

Yoshiyama, H

Imai, S

Shimizu, N

Takada, K

机构：

[1] HOKKAIDO UNIV, SCH MED, INST CANC, DEPT VIROL, KITA KU, SAPPORO, HOKKAIDO 060, JAPAN

[2] YAMAGUCHI UNIV, SCH MED, DEPT MICROBIOL, UBE, YAMAGUCHI 755, JAPAN

[3] TOKYO MED & DENT UNIV, MED RES INST, TOKYO 113, JAPAN

来源：

JOURNAL OF VIROLOGY | 1997年 / 71卷 / 07期

关键词：

D O I：

10.1128/JVI.71.7.5688-5691.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recombinant Epstein-Barr virus (EBV) with a selectable marker successfully infected the human gastric carcinoma cell lines AGS, MKN28, and MKN74. Following incubation in selective media, drug-resistant cell clones were isolated and proved to be infected with EBV. All gastric carcinoma cell clones were positive for EBNA 1 bat negative for EBNA 2. LMP 1 expression was negative in most clones, but there were a few exceptions, Gastric carcinoma cells were negative for the EBV receptor CD21, and infection was not inhibited by pretreatment of cells with the anti-CD21 monoclonal antibody OKB7, The results indicate that gastric carcinoma cells are susceptible to EBV infection and that infection is mediated via a new receptor different from CD21.

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页码：5688 / 5691

页数：4

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