Pharmacokinetics of amprenavir and lopinavir in combination with nevirapine in highly pretreated HIV-infected patients

被引：10

作者：

Fätkenheuer, G ^{[1
]}

Römer, K

Kamps, R

Salzberger, B

Burger, D

机构：

[1] Univ Cologne, Dept Internal Med, D-5000 Cologne 41, Germany

[2] Univ Nijmegen, Dept Clin Pharmacol, Nijmegen, Netherlands

来源：

AIDS | 2001年 / 15卷 / 17期

关键词：

D O I：

10.1097/00002030-200111230-00021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A pharmacokinetic study was performed in five patients treated with the combination of amprenavir, lopinavir and nevirapine. Although the concentrations of amprenavir were within the expected range, lopinavir concentrations varied widely and tended to be lower than predicted by the manufacturer. We concluded that therapeutic drug monitoring should be performed when this combination is applied.

引用

页码：2334 / 2335

页数：2

共 6 条

[1]

*ABB LAB, 2000, KAL PACK INS N CHIC

[2]

BECKER S, 2000, 40 INT C ANT AG CHEM

[3] Simultaneous determination of the HIV-protease inhibitors indinavir, nelfinavir, saquinavir and ritonavir in human plasma by reversed-phase high-performance liquid chromatography [J].

Hugen, PWH ;

Verweij-van Wissen, CPWGM ;

Burger, DM ;

Wuis, EW ;

Koopmans, PP ;

Hekster, YA .

JOURNAL OF CHROMATOGRAPHY B, 1999, 727 (1-2) :139-149

[4]

PEYTAVIN G, 2001, 2 INT WORKSH CLIN PH

[5] Pharmacokinetics and safety of amprenavir and ritonavir following multiple-dose, co-administration to healthy volunteers [J].

Sadler, BM ;

Piliero, PJ ;

Preston, SL ;

Lloyd, PP ;

Lou, Y ;

Stein, DS .

AIDS, 2001, 15 (08) :1009-1018

[6] Pharmacokinetic and pharmacodynamic study of the human immunodeficiency virus protease inhibitor amprenavir after multiple oral dosing [J].

Sadler, BM ;

Gillotin, C ;

Lou, Y ;

Stein, DS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (01) :30-37

← 1 →