Immunity to tuberculosis

被引:515
作者
North, RJ [1 ]
Jung, YJ [1 ]
机构
[1] Trudeau Inst Inc, Saranac Lake, NY 12983 USA
关键词
Th1; immunity; CD4 T cells; interferon-gamma; nitric oxide synthase; lung pathology;
D O I
10.1146/annurev.immunol.22.012703.104635
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Only 5 to 10% of immunocompetent humans are susceptible to tuberculosis, and over 85% of them develop the disease exclusively in the lungs. Human immmodeficiency virus (HIV)-infected humans, in contrast, can develop systemic disease that is more quickly lethal. This is in keeping with other evidence showing that susceptible humans generate some level of Thl immunity to Mycobacterium tuberculosis (Mtb) infection. Tuberculosis in mice is also exclusively a lung disease that is progressive and lethal, in spite of the generation of Thl-mediated immunity. Thus mouse tuberculosis is a model of tuberculosis in susceptible humans, as is tuberculosis in guinea pigs and rabbits. Inability to resolve infection and prevent disease may not be a consequence of the generation of an inadequate number of Thl cells but of an intrinsic deficiency in macrophage function that prevents these cells from expressing immunity. If this proves to be true, vaccinating susceptible humans against tuberculosis will be a difficult task.
引用
收藏
页码:599 / 623
页数:25
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